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The observation that the insulinotropic actions of GLP-1 are reduced in type 2 diabetes mellitus (T2DM) led to the development of incretin-based therapies GLP-1 receptor agonists and dipeptidyl peptidase 4 (DPP-4) inhibitors for the treatment of hyperglycaemia in these patients

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The combination of CJC-1295 and Ipamorelin is used to provide a more physiologic growth hormone pattern than either peptide alone, and when combined, they produce a 3-5 fold increase in growth hormone levels